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Research has examined GHK-Cu's interactions with collagen synthesis pathways, metalloproteinase systems, and growth factor expression including vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF)

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Laser Treatment for Pigmentation Lasers like Q-switched Nd:YAG, Pico Laser, or Fractional CO2 target melanin pigment directly without damaging surrounding skin

Improvements in skin tone and brightness may diminish gradually after stopping use

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