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Acknowledgements This work was supported by the National Natural Science Foundation of China [grant numbers 82125037], Science Foundation for Distinguished Young Scholars of Jiangsu province [grant number BK20231528], Key R&D Program of Jiangsu Province [grant number BE2022815], Jiangsu Provincial Medical Innovation Center [grant number CXZX202225], Young Elite Scientists Sponsorship Program of the China Association for Science and Technology [grant number 2021-QNRC2-B17], and 333 high-level talents project of Jiangsu Province for Yang Yang [grant number BRA202202]

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In another study that examined the role of exenatide in improving coronary endothelial function in newly diagnosed type 2 diabetic patients in a randomized controlled trial, the coronary endothelial function was assessed by measuring the coronary flow velocity reserve (CFVR) which was improved significantly after 12 weeks of treatment with exenatide, CFVR was correlated inversely with hemoglobin A1c (Hb A1c) and positively with high-density lipoprotein cholesterol (HDL-C), this was also associated with a decrease in serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) was remarkably decreased in the exenatide treatment group compared with the baseline and the control group emphasizing the anti- inflammatory effects of exenatide