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These microvascular changes are believed to play a crucial role in both the onset and progression of lipedema.15 Additionally, pain in lipedema appears to be multifactorial

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Meaning These findings complement early results from small clinical trials and support the use of semaglutide and tirzepatide in patients with cardiometabolic heart failure with preserved ejection fraction

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Moreover, pevonedistat treatment rescued the expression of key fatty acid transport and oxidation molecules (Figs