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Moran et al., 2000)

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TGF- is a cytokine exerting immunosuppressive functions in the TME (112) and it was shown to modulate the expression of CD16 and thus the NK cell cytotoxic potential (113)

Of note, non-neuronal cells of various tissues and organ systems also synthesize and release acetylcholine, which then binds and stimulates cholinergic receptors on target cells (reviewed in 6)

The title slide had a photo of a Ken doll with a syringe pointed at its forehead