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GLP-1 es una va hormonal relacionada con el apetito y la saciedad

Wegovy is FDA-approved specifically for chronic weight management at a higher dose (2.4 mg versus Ozempics 1 mg maximum)

Blood pressure actually improved in most participants, a benefit attributed to weight loss and improved insulin sensitivity outweighing any direct cardiovascular stimulation from the drug itself

(15) In a separate animal study by Mieczkowska et al., a comparison of liraglutide to dapagliflozin on bone strength and microarchitecture in insulin-resistant and obese mice found no indication of improved bone strength or microarchitecture by either substance

If you consider that your dose matters quite a bit in terms of how much weight patients lose, then you can easily understand that more efficacious medications are likely to result in even more weight loss than metformin

Metformin improves endothelial function and reduces systemic inflammation, while semaglutide decreases arterial stiffness and improves lipid profiles