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In June 2023, Pfizer announced the progress of its oral late-stage glucagon-like peptide-1 receptor agonist (GLP-1-RA) candidate toward first clinical development for the potential treatment of adults with obesity and Type 2 diabetes mellitus (T2DM)

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Ozempic, which contains the active ingredient semaglutide, has been linked to severe gastrointestinal issues, including gastroparesis (delayed stomach emptying) and pancreatitis

Animal Data Phentermine/Topiramate Embryo-fetal development studies have been conducted in rats and rabbits with combination phentermine and topiramate treatment

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