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Defects in the gene that helps stimulate production of IGF-1 causes insulin-like growth factor 1 deficiency, which is associated with stunted growth and development
All DSIP therapy requires a physician consultation and prescription
Potential side effects could include mild nausea, headaches, or allergic reactions, though these are rare
In various clinical trials, doses ranging from 250 mg to 1,000 mg per day have been used without significant adverse events
We predicted that upon rescue by APR-246, sensitive TP53 mutants would regain apoptotic activity and self-select themselves out of the variant population
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