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Subsequent assay studies indicated that (R)-3-amino-1-(2-benzoyl-1,2-diazepan-1-yl)-4-(2,4,5-trifluorophenyl) butan-1-one (40) possesses strong in vitro activity, favorable selectivity, and in vivo efficacy in mouse models (Figure 6)

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Por otro lado, es importante decirlo con claridad: los medicamentos tipo GLP-1 son de los tratamientos ms exitosos que tenemos hoy para obesidad y diabetes, en los pacientes que los toleran

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