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Characterization: "Not Well-Characterized" FDA concluded that both the free base and acetate forms are not well-characterized physically and chemically, citing (1) inconsistent naming conventions that do not follow established nomenclature standards (USAN, INN, IUPAC), and (2) missing substance-specific quality-control data

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Inflammation, repair signaling, angiogenesis, immune modulation, and remodeling occur at the same time

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Adding to doctors' worries are concerns about purity and dosing, because users typically buy from websites selling unregulated Chinese product some of which comes from plants that previously produced the deadly opioid fentanyl