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[DOI] [PMC free article] [PubMed] [Google Scholar] 38.Kern J.C., Dooney D., Zhang R., Liang L., Brandish P.E., Cheng M., et al

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At much higher concentrations, melatonin may act as an electron donor, promoting a receptor free non-specific antioxidant response ( Melatonin receptors MT1 and MT2 couple to Gi/o and beta-arrestins and depending on the context also couple to Gq ( Pineal melatonin exerts a wide range of physiological actions due to its release into the cerebrospinal fluid (CSF) and bloodstream