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In clinical trials, the most common side effects of Retatrutide were mild digestive symptoms like nausea, diarrhoea, vomiting, and constipation.These were dose-related, generally mild to moderate, and tolerability improved with slower titration

These latter data are translationally important as loss of functional -cells with T2DM has been linked to dedifferentiation and reduced insulin secretion 58

For instance, one subgroup of real-world patients who maintained high adherence and stayed on high maintenance doses reported an average weight loss of 13.7% of their body weight

Overall, the research suggests that both retatrutide and tirzepatide are highly effective at lowering HbA1c levels

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