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However, more testing and evidence is required to determine their efficacy and safety

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the four-peptide combination itself has not been studied in large controlled trials, but the mechanistic rationale builds on well-documented pathways for each individual compound

A prospective RCT with dual metabolic and psychiatric endpoints, enrolling patients with active depression or anxiety plus diabetes or obesity, stratified by SUD comorbidity and baseline anhedonia severity that trial is buildable, and the recruitment population is not hypothetical