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Thus, in addition to a direct role of the paraventricular hypothalamic nucleus to regulate energy balance and glucose metabolism, neurons in the paraventricular hypothalamic nucleus function as an important relay for various circuits including melanocortin neurons, which contribute to proper metabolic regulation

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By integrating the network graph and the topological attributes table, we identified five key targets associated with UC, including REN, LNPEP, HLA-A, OXTR, and SIRT1

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Materials and methods The study follows the PRISMA statement [16] and Cochrane Handbook [17]