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In 2020, Qwo (collagenase clostridium histolyticum-aaes) was FDA approved for the treatment of moderate to severe buttocks cellulite

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After 30 days, when mice in both the HFD-SY and HFD-WM groups reached the weight range of lean age-matched control mice, treatment was withdrawn and the glucose-lowering efficacy of the interventions was determined by measuring hyperglycaemia, hyperinsulinaemia and insulin resistance