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The current understanding, shaped largely by tirzepatide research, is more nuanced GIPR activation appears synergistic with GLP-1R activation in contexts where single-receptor work predicted a smaller signal

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The discovery, characterization, and clinical development of glucagon-like-peptide-1 (GLP-1) spans more than 30 years and includes contributions from multiple investigators, science recognized by the 2017 Harrington Award Prize for Innovation in Medicine

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