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Compounded medications undergo rigorous testing for purity, potency, and sterilitythough they are not FDA-approved as finished products

Larger deviations (6+ hours early or late) dont invalidate the dose but may cause temporary side effect amplification as plasma concentrations fluctuate outside your bodys adapted range

The FDA states that additional studies are needed to assess safety and efficacy before leucovorin calcium approval for this patient population

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Put that in context

Injection timing is one lever for protecting training quality not by avoiding training, but by not scheduling the most demanding sessions during the highest-symptom post-injection window