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Legal Classification IGF-1 LR3 and DES : Not classified as controlled substances, but not approved for medical use Sale for human consumption : Illegal under FDA regulations Possession : Legal for research purposes, but not for ingestion or injection in humans The FDA has not evaluated IGF-1 peptides for safety or effectiveness in humans

The appearance is consistent across patient ages, though older patients tend to experience it more dramatically because they have less collagen reserve and less skin elasticity to compensate for the structural changes

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