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It works as a dual GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptor agonist meaning it mimics the natural hormones your body uses to regulate appetite and digestion

They titrate fast because they want results fast

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My Protocol: Started at 0.5 mg weekly, titrated to 4 mg over 12 weeks

Retatrutide has been linked with increases in resting heart rate in clinical trials

However, it is essential to note that when additional pharmacological intervention is required to control diabetes mellitus, the choice between SGLT-2 inhibitors and GLP-1 RAs should be based on the patients individual needs and the specific medications already being used