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PI3K-AKT-mTOR Pathway The PI3K-AKT-mTOR pathway is another frequently activated oncogenic signaling cascade in MM, which is verified by elevated AKT phosphorylation through immunohistochemical staining (102, 103)

Its dual GLP-1/GIP mechanism can increase metabolic strain

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2 Organ-on-chip in the 3D in vitro models framework OoCs allow researchers to model human diseases in the lab using immortalized or donor-derived cells cultured in organ-specific microenvironments