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High concentrations of H 2 O 2 in the epidermis are toxic to melanocytes because they inhibit tyrosinase and deactivate catalase

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Under normal conditions, the activity of the Nrf2-mediated transcription is low, as most of Nrf2 protein is degraded in the proteasome ( REGULATORY MECHANISMS OF NRF2 ACTIVITY Keap1 was identified as a cytoplasmic Nrf2-interacting protein that negatively regulates Nrf2 activity (Wakabayashi et al., 2003)