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June 2025: The European Medicines Agencys (EMAs) safety committee concluded that NAION is a very rare potential side effect of semaglutide medicines, like Wegovy

38,5658 However, instead of enhancing the injury mechanism as intended, this modulation changed the injury process altogether from a protein adduct-driven signaling process to one dominated by LPO

The FDA and American Diabetes Association strongly recommend using a new needle for each injection

Patients with longstanding diabetes and established autonomic neuropathy face elevated baseline gastroparesis risk independent of GLP-1 use, making causality attribution particularly challenging in this population

If palpitations occur, sit down, take slow deep breaths, and rest for 1015 minutes