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A recent retrospective cohort analysis revealed that, compared to the combination of SGLT-2 inhibitors with insulin, the concomitant use of GLP-1RAs and insulin was associated with a significantly elevated risk of DR and diabetic macular edema [80]

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Impaired cerebral perfusion compromises white matter integrity, deteriorates neural connectivity, and facilitates neurodegenerative processes ( The metabolic events most closely associated with AD include insulin resistance, hyperglycemia, lipid dysregulation, mitochondrial dysfunction, and oxidative stress

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