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According to some scientists, hydrogen peroxide (H 2 O 2 ) also belongs to this group since it easily penetrates the membranes and in the presence of transition metals (copper or iron) it can be reduced to OH as in the example below (Yu, 1994): Hydroxyl radical is the strongest oxidant generated in biological systems because of its extremely short half-life (Yu, 1994

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Miotto GM, Rossetto ML, Di Paolo, et al

Glycocalyx recovery in patients takes approximately 24 h after crystalloid resuscitation, but may take up to 5 days in animal models [115]