But the TMAO production creates potential cardiovascular risks that require careful consideration, especially for long-term use
In landmark studies by Sinclair and colleagues at Harvard Medical School, restoration of NAD+ levels in aged mice through precursor supplementation resulted in dramatic improvements in mitochondrial function, with aged tissue resembling that of much younger animals within one week of treatment
Given the intractable pediatric obesity epidemic and associated rise in type 2 diabetes in youth, made worse by the COVID-19 pandemic related shutdowns and disruptions in opportunities for exercise and play in youth, this new class of medications will certainly benefit children with morbid obesity and type 2 diabetes
That price gap has pushed thousands of people toward unregulated sources, buying raw active ingredients from overseas and preparing injections at home
And some research has raised, if not red flags, perhaps a few yellowish ones
[PubMed: 19644802] 65a