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Salameh et al., 2020

As mentioned earlier, deep sleep is a necessary condition for growth hormone release

Some patients experience mild tremors or shivers as their body adjusts to appetite suppression and weight loss, while others notice that their hands and feet feel colder than before starting treatment

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By contrast, in fbf-1 fbf-2 double mutants, GSCs are maintained until the L4 stage, but most GSCs leave mitotic cell cycle, enter meiosis, and eventually differentiated into sperm (Glp phenotype) (Crittenden et al., 2002)