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A recent study combining single-nucleus sequencing and spatial transcriptomics pinpointed the human hypothalamic GLP-1R-LepR co-expressing cluster, which strongly correlated with the mouse hypothalamic cluster that exhibits the second highest expression of GLP-1R in the hypothalamus [76]
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Amato A, Cinci L, Rotondo A, Serio R, Faussone-Pellegrini MS, Vannucchi MG, et al
For those specifically targeting visceral fat reduction , the 12mg dose provides the strongest metabolic activation
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Numerous cell types, including endothelial cells, tanycytes, and neurons in the hypothalamus and hindbrain express GLP- 1, GIP receptors and glucagon receptor, and
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