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Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

Using CRISPR-Cas9 in human and mouse cells, genome-wide, targeted loss-of-function pooled screens have been studied that has provided information about the inactivated genomic loci and strategies that modulate transcriptional activities (Shalem et al., 2015)

The endpoint of the trial was reached when the tumors grew to the size limit (15 mm in diameter)

Ferroptosis: a novel anti-tumor action for cisplatin

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