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In contrast with adaptive immunity, which encompasses antigen-specific responses by T and B lymphocytes, trained immunity is characterized by antigen non-specific tissue adaptation to acute and chronic inflammation, sometimes in response to infection, and has been predominantly studied in professional innate immune cells such as macrophages, monocytes, dendritic cells and natural killer cells 23,24,25

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El-Andaloussi S, et al

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It is widely known for its effectiveness in treating nerve disorders, B12 deficiency, and neuropathic pain

doi:10.1186/1471-244X-13-196 Child DF, Hudson PR, Jones H, Davies GK, De P, Mukherjee S, Brain AM, Williams CP, Harvey JN (2004) The effect of oral folic acid on glutathione, glycaemia and lipids in type 2 diabetes