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Aruoma OI, Halliwell B, Hoey BM, Butler J

At the molecular level, these observations are corroborated by the disrupted regulation of proteins that promote cell proliferation, such as cyclin D1, and those that form barrier-tight junctions, including zonula occludens-1, occludin, and claudins 1, 4, and 8 (Birder, 2019)

5 Conclusion Collectively, it can be concluded that MTX-induced hepatotoxicity is mediated, at least in part, through ER stress, which was confirmed by the reversal of MTX toxicity upon administration of 4-PBA and NAC

Cross, M

found that 37.5% of participants completed 12 injections compared to 18.7% in the placebo group, suggesting modest efficacy