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The work shows that LXA4 acts via the ESR2/LPAR3/Nrf2 axis to provide its anti-inflammatory and anti-ferroptotic actions in vitro cell co-culture and in vivo rat models, offering a novel therapeutic target for the intervention of KOA [110]

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Future studies could focus on optimizing the molecular structure of flavonoids, which may yield structurally modified derivatives with enhanced pharmacological potency

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