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At week 8, 51.6% patients treated with ALC met the primary endpoint, compared with 23.1% of patients in the placebo group

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overactivation of PARPs, such as during extensive genotoxic stress, can result in significant NAD + depletion and subsequent compromise of cellular energy homeostasis

Clinical data were retrieved from the electronic medical records, and morphologic features, maximal mitotic counts, Ki67 labeling indices, and immunohistochemical profiles (SOX10, SOX2, p75NTR, p16, p53, EGFR, and neurofibromin) were assessed

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