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Peer review Peer review information Nature Cancer thanks Andrew Hoy, Michael Pollak, ngela Valverde and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

It simultaneously targets GLP-1, GIP, and glucagon receptors, showing superior results in preclinical studies for weight management, energy expenditure, body composition, hepatic lipid metabolism, NASH/NAFLD, thermogenesis, and long-term metabolic homeostasis

316 , F231F240 (2019)

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Some GLP-1 agonists have demonstrated cardiovascular risk reduction in clinical trials