Am J Physiol Cell Physiol
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Common symptoms include nausea, constipation, diarrhea, bloating, and appetite suppression
The conversion guidance that exists for transitioning between other GLP-1 agonists can provide some framework for thinking about dosing during transitions, though no specific tirzepatide-to-retatrutide conversion protocol has been established in clinical literature
GLP-1 produces therapeutic effects via synchronized activities within the pancreatic, gastrointestinal, and central neurological systems, making it optimal for the dual control of diabetes and obesity (see to Table 1 for comprehensive mechanisms) (Ruze et al
5.4.1 Effects on adipose tissue GIPRs are abundant in adipose tissue (170)