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Kaczmarzyk et al

It drives the transition from proliferation to differentiation and increases the number and length of multinucleated myotubes in a dosedependent manner.The mechanism is mainly related to NNMT inhibition, restored NAD levels, and activation of the SIRT1PGC1 pathway

GLP-1 medications (including FDA-approved options such as semaglutide and tirzepatide) have been associated with greater average weight loss in clinical trials

GLP-1 produces continued, compounding loss

Autoimmune and inflammatory conditions Patients with autoimmune conditions including lupus, rheumatoid arthritis, and Hashimoto thyroiditis have increasing access to GLP-1 therapy, and the anti-inflammatory mechanism provides specific rationale for this use

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