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Q 2: Is dual-action therapy more effective than GLP-1 alone

Similarly, Mounjaro, by targeting both GIP and GLP-1 receptors, offers a novel method for managing weight, potentially enhancing the durability of weight loss outcomes

This includes resveratrol, curcumin, quercetin, baicalein, berberine and epigallocatechin gallate (EGCG), which have demonstrated pleiotropic neuroprotective effects by mitigating oxidative and inflammatory cascades, improving mitochondrial biogenesis, preventing proteostasis imbalance, and/or blocking -synuclein aggregation

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Discussion AWE presents a significant challenge in management due to its impact on quality of life and limited treatment options [6]

The SELECT cardiovascular outcomes trial actually demonstrated cardiovascular benefit rather than harm, which was reassuring