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Implication of trimethylamine N -oxide (TMAO) in disease: potential biomarker or new therapeutic target

Triglycerides decreased by 35-40%

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Collectively, these findings establish ROS as critical enablers of HCC metastasis, orchestrating EMT, proteolytic matrix degradation, and distant organ colonization through coordinated activation of ERK/AKT, JNK, and NF-B signaling [91], thereby providing a mechanistic basis for the link between oxidative stress and poor clinical outcomes in HCC