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ROS can mutate genes, such as those for cystathionine--synthase (CBS), decreasing cysteine production and raising homocysteine (Hcy) levels

It should be avoided or used only under clinician supervision in patients with kidney disease, older adults, or those at risk for electrolyte abnormalities , due to the risk of hypermagnesemia., Use sparingly: Stimulant laxatives (such as bisacodyl or senna) may be effective for intermittent rescue use , but they can cause cramping and are generally not needed for routine long-term management when osmotic agents are effective., Safety note: Regular stimulant laxative use that causes frequent loose stools may contribute to dehydration and electrolyte imbalance (including hypokalemia) and should therefore be intermittent unless clinician-directed . What about docusate (Colace)

It helps control acne-causing bacteria while protecting the collagen-producing cells that keep your skin looking youthful

& Hirose, M

Clin Hematol 4:83, 1975

Influence of glutathione S-transferases on cellular glutathione determination by flow cytometry using monochlorobimane