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Funding This study was supported by the Hebei Province Natural Science Foundation (H2022307026)

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It's important to note that while L-Carnitine has shown promise for skin health in some studies, more research is needed to establish its effectiveness and safety as a skincare ingredient

Abbreviations GLP-1RA: Glucagon-like peptide-1 receptor agonist(s) IPTW: Inverse probability of treatment weighting SGLT-2i: Sodium-glucose cotransporter 2 inhibitor(s) SIS: Suicidal ideation and self-injury VHS: Valencia Health System VID: Valencia Health System Integrated Database References Davies MJ, Aroda VR, Collins BS et al (2022) Management of hyperglycemia in type 2 diabetes, a consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

All these factors influence brain homeostasis (red arrow)