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Diabetes Obes Metab 22(12):24872492 Verma S, Bhatta M, Davies M, Deanfield JE, Garvey WT, Jensen C, et al (2023) Effects of once-weekly semaglutide 2.4 mg on C-reactive protein in adults with overweight or obesity (STEP 1, 2, and 3): Exploratory analyses of three randomised, double-blind, placebo-controlled, phase 3 trials

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Clinical Trial Results: Tirzepatide Shows Stronger Weight Loss Major Phase 3 trials demonstrate that tirzepatide consistently outperforms semaglutide in weight reduction metrics

The downstream consequences include enhanced glucose uptake into skeletal muscle independent of insulin, increased fatty acid oxidation, and suppression of inflammatory signaling

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