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No change in extracellular GSH levels were observed after 12 hours of CSE exposure, but by 24 and 48 hours there was significantly more extracellular GSH with CSE exposure versus the control (Figure 1A)

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Thats because melatonin has shown to help reduce oxidative stress within the cells of the placenta, according to research in the International Journal of Molecular Sciences

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Notably, HSP70 has been shown to interact with catalase-associated pathways, further augmenting antioxidant defenses and improving cardiac function following ischemic injury

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