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Folic acid, folinic acid, 5 methyl tetrahydrofolate supplementation for mutations that affect epigenesis through the folate and one-carbon cycles

Tanaka M, Schally AV, Telegdy G

The NHS provides evidence-based B12 replacement therapy for documented deficiency using standardised hydroxocobalamin protocols, but does not endorse lipotropic injections for weight management

However, investigation of these factors in preclinical studies is limited due to the time and expense of generating transgenic mice and the variability of the currently available rodent models 20

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