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The Bridge is designed to lay the groundwork for a follow-on program called the BALANCE Model, but that model's implementation in Medicare Part D in 2028 remains contingent on plan participation and regulatory decisions that have not yet been finalized

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Discontinuation due to adverse events runs approximately 4-7% across studies, which is comparable to other GLP-1 receptor agonists

Efficacy and safety of retatrutide, a novel GLP-1, GIP, and glucagon receptor agonist for obesity treatment: a systematic review and meta-analysis of randomized controlled trials

However, medication alone is not the entire solution