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NBDHEX acts as a mechanism-based inhibitor of GSTP1-1, where it is first recognized as a substrate and makes a spontaneous intermediate - complex with GSH, which binds very tightly to the enzyme and results in the loss of both the GSH-conjugating activity as well as the ability to form complexes with partner proteins JNK1 and TRAF2 [62,95,97]

This comprehensive caviar/roe metabolite map proposes male gilt-head bream Sparus aurata and female common cuttlefish Sepia officinalis for further investigation of their potential functional food applications, driven by their rich omega-3 PUFA levels

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Published October 6, 2025