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In this scenario, it is argued that even if trypomastigotes are more dependent on glycolysis than oxidative phosphorylation for their energy need (Bringaud et al., 2009), they may still be exposed to excessive oxidative stress due to mitochondrial remodeling and increased ROS production (Gonalves et al., 2011)

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Intracranial Anti-Tumor Activity with Encorafenib Plus Binimetinib in Patients with Melanoma Brain Metastases: A Case Series

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For NCT02475213, patients with non-small cell lung cancer, head and neck squamous cell carcinoma, urothelial cancer and melanoma, were treated with enoblituzumab (investigational anti-B7H3 antibody), together with pembrolizumab, anti-PD1 inhibitor

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