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PMCID: PMC4096488.

No completed, published Phase II human trial exists for either route as of mid-2025

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Furthermore, it is of note that the changes of gene mRNA expression do not directly reflect the enzyme activities or protein functions, therefore, the regulatory mechanisms of L-carnitine at the transcriptional level still need further functional validation

In addition to its metabolic functions, L-carnitine exhibits antioxidant, anti-inflammatory, and cytoprotective properties by attenuating oxidative stress and influencing key inflammatory pathways (Fathizadeh et al

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