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Because of lack of sensitivity and problems with non-specificity of commercially available GLP-1R antisera detected multiple nonspecific immunoreactive proteins even in tissue extracts from Glp1r -/- mice

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Metabolic byproducts such as 2-deoxy-D-ribose also trigger ferroptosis by degrading the core subunit of System Xc (xCT) and consuming GSH (Kim et al., 2023)

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In view of the pivotal role played by GSH in redox system and the relationship between oxidative stress and autophagy 68 , it is conceivable that GSH depletion-induced oxidative stress and lipid peroxidation may be a key point linking ferroptosis and autophagy in RPE cells

This prolonged diagnostic process is compounded by differences in exclusion criteria across various definitions of ME/CFS, as highlighted by Jason et al., 2012 (54)