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This peptide hormone regulates calcium homeostasis and bone metabolism, addressing the underlying pathophysiology of these bone disorders

Thus, reducing female Kdm5c gene dosage to a single allele as is present in male mice prevents statin-induced impairment of glucose tolerance, redox tone, mitochondrial activity, and fatty acid gene expression

However, the absence of human clinical trials means the safety profile in humans is entirely unknown

In contrast to genetic mutations, epigenetic modifications rapidly affect target cell types exerting a long-lasting control in gene expression and provide a mechanism for a non-genomic inheritance

10.1186/s40001-025-02524-4 Eur J Med Res

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