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At the same time, it fine-tunes which collagen-clearing enzymes are active, striking a balance between breaking down old tissue and building new tissue, while also calming inflammation

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doi: 10.1093/FAMPRA/CMAB076 34 BansalRGubbiSKochCA

Here, by consolidating data on differential methylation in the Bangladeshi women who had grown in Bangladesh (more pathogenic environment) or the UK, together with differences in ovarian gene expression in a mouse model of prepubertal immune challenge, we identified the downregulation in SRD5A1

A.et al (2007)

In addition corticosteroids have been associated with local skin atrophy, depigmentation and muscle wasting