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PROTAC-based approaches have been developed to selectively degrade aggregation-prone proteins, including QC-01-C175 for tau in AD, XL01126 for LRRK2 in PD, and GW5074 for mutant huntingtin in HD

Ciclopirox olamine induces ferritinophagy and reduces cyst burden in polycystic kidney disease

Regular IGF-1 has 70 amino acids, while Long R3 IGF-1 has 83 amino acids due to the addition of 13 amino acids on its N-terminal end

Use as an active pharmaceutical ingredient (API) in compounding, manufacturing, or drug formulation

Direct injection showed high efficiency in inhibiting the proliferation of cancer cells and decreasing tumor mass (135)

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