2023 Feb 1;46(2):384-390 Baxter SM, Lund LC, Andersen JH, et al
New England Journal of Medicine 389 (10)
Retatrutide is a weekly injection that is slightly more sophisticated than other GLP-1 drugs because it is a "triple agonist." Unlike current drugs (Zepbound, Ozempic-type medications) that target one or two hormone pathways, retatrutide activates three hormone receptors (GIP, GLP-1, and glucagon) at once
Furthermore, by improving overall insulin sensitivity, GLP-1RAs decrease the toxic influx of free fatty acids from adipose tissue to the liver, thereby mitigating hepatic lipotoxicity (Wang et al., 2017)
Compounded medications, on the other hand, are produced by either a state-licensed pharmacy or physician, or an FDA-registered outsourcing facility
Enter peptides like CJC-1295, ipamorelin, tesamorelin, and sermorelin, which all facilitate the bodys release of growth hormone from the pituitary gland